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Experimental Amyloidosis in Mice: Effect of high and low protein diets

Department of Anatomy, Downstate Medical Center, State University of New York, Brooklyn, New York

Results of past studies concerning the relation of high and low protein diets to the development of sodium caseinate-induced amyloidosis in mice have been somewhat conflicting. A study was therefore made to reanalyze these factors using the more chemically defined diets now available. C3HeB/FeJ male mice were fed the experimental diet when 9 weeks of age; 2 weeks later caseinate injections were initiated and were given 5 times a week for 10 weeks. All animals were weighed weekly and spleen and liver weights were taken at autopsy. The proportion of amyloid deposits in sections of the spleen and liver was determined by the Chalkley method for the quantitative morphologic analysis of tissues. Neither the high casein nor low casein diets prevented the development of amyloidosis. The results suggest that the high casein diet tends to favor the development of amyloid disease. Although the low casein diet tended to inhibit the development of amyloid disease, the results were inconclusive. Morphologically, these effects were observed primarily in the liver. Organ weight data and survival of the injected animals suggest that these effects pertain to the general picture of amyloid disease in these animals.

Manuscript received 11 December 1967.