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Journal of Nutrition Vol. 95 No. 2 June 1968, pp. 191-196
Copyright © 1968 by American Society for Nutrition
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Copper-Molybdenum Interaction in Sheep and Chicks1, 2,

Richard P. Dowdy3,4 and Gennard Matrone

Departments of Biochemistry and Animal Science, North Carolina State University, Raleigh, North Carolina

A series of experiments was conducted in an attempt to gain further insight into the biological interaction between copper and molybdenum. In sheep fed a purified, low copper diet containing varying levels of molybdenum and inorganic sulfate, anemia developed only in those animals receiving molybdenum. All these sheep showed a diminution of plasma copper as the trial progressed. High levels of dietary molybdenum did not significantly depress the induction of ceruloplasmin activity in chicks stressed with fowl typhoid. High levels of molybdenum in the incubation solution reduced the in vitro uptake of copper by rat liver and kidney slices. It was observed that CuSO4 and Na2MoO4 form a complex which precipitates in a near neutral solution. The ratio of copper to molybdenum in this complex was 4:3. The results of these studies were used to develop a hypothesis that molybdenum complexes with copper and that copper bound in this state is biologically inactive.

1 Contribution from the Departments of Biochemistry and Animal Science, School of Agriculture and Life Sciences, and School of Physical Sciences and Applied Mathematics, paper number 2533 of the Journal Series of the North Carolina State University Agricultural Experiment Station, Raleigh, North Carolina.

2 Supported in part by a grant from the Herman Frasch Foundation and Public Health Service Research Grant no. AM-05651-05 from the National Institute of Arthritis and Metabolic Diseases.

3 This report constitutes a portion of a thesis submitted by Richard P. Dowdy in partial fulfillment of the requirements for the degree of Doctor of Philosophy.

4 Current address: U. S. Army Medical Research and Nutrition Laboratory, Fitzsimons General Hospital, Denver, Colorado.

Manuscript received 27 November 1967.




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