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Journal of Nutrition Vol. 95 No. 2 June 1968, pp. 184-190
Copyright © 1968 by American Society for Nutrition
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Some Effects of Amino Acid Deficiencies on Antibody Formation in the Rat1

Stanley N. Gershoff, Thomas J. Gill, III, Simon J. Simonian and Arthur I. Steinberg

Department of Nutrition, Harvard School of Public Health and Laboratory of Chemical Pathology, Department of Pathology, Harvard Medical School, Boston, Massachusetts

The effects of a variety of nutritional deficiencies on antibody formation in rats have been studied. Deficiencies of vitamin B6, tryptophan and phenylalanine in rats decreased the antibody response to the synthetic antigen, poly Glu52Lys33Tyr15 (no. 3) or to the natural antigen, sheep red blood cells. Methionine deficiency, methionine excess, or caloric restriction did not alter the antibody response. The metabolic antagonist deoxypyridoxine further decreased the antibody response in vitamin B6-deficient rats. The effect was reversed partially by glycine or serine, serine being more effective on a molar basis. Ethionine, a methionine antagonist decreased the antibody response, and its effect was not reversed by adenine or by methionine. The antibody response in germfree rats was higher than in normal animals.

1 Supported in part by a contract from the U. S. Army Research and Development Command (DA 49-193-MD-2792), by grants from the National Institutes of Health (AM-7618 and AM-03056), and the Fund for Research and Teaching, Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts. Dr. Gill is the recipient of a Research Career Development Award from the National Institutes of Health (K3-AM-5242). Dr. Steinberg received support from U.S.P.H.S. Training Grant 5T01 DE 00111.

Manuscript received 29 January 1968.


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M. Sela
Antigenicity: Some Molecular Aspects
Science, December 12, 1969; 166(3911): 1365 - 1374.
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