Journal of Nutrition OpenSOurce Diets- www.ResearchDiets.com

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

Journal of Nutrition Vol. 95 No. 1 May 1968, pp. 19-22
Copyright
This Article
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Fleischman, A. I.
Right arrow Articles by Bierenbaum, M. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Fleischman, A. I.
Right arrow Articles by Bierenbaum, M. L.

Effect of Calcium and Vitamin D3 upon the Fecal Excretion of Some Metals in the Mature Male Rat Fed a High Fat, Cholesterol Diet1

Alan I. Fleischman2, H. Yacowitz3, Thomas Hayton2 and Marvin L. Bierenbaum2

Atherosclerosis Research Center, St. Vincent's Hospital, Montclair, New Jersey and Health Research Institute, Fairleigh Dickinson University, Madison, New Jersey

The effect of elevated dietary calcium upon the excretion of 10 metals was studied in 400-day-old male Holtzman albino rats. Increasing dietary calcium from 0.08% to 1.2% increased excretion of lead, nickel, copper, cadium, chromium, iron, manganese, zinc, cobalt and magnesium when the rats were fed a corn-soya diet containing 18% added fat as USP cocoa butter and 2% added cholesterol. Inclusion of 25 units of vitamin D3 /g of feed partially or completely inhibited the ability of elevated dietary calcium to cause increased excretion of these metals. Although supplementation of a diet with some essential metals may possibly be required, elevated levels of dietary calcium appear to entail the dual effects of lowered serum lipids, without deposition in tissue, and of increased fecal excretion of some potentially deleterious metals.

1 This work was supported in part by a grant from the National Institutes of Health, H-5905, a contract in aid from the New Jersey State Department of Health, a grant from the Morris County Heart Association, and a grant from the Sandoz Corporation to one of the investigators (H. Y.).

2 Atherosclerosis Research Group, St. Vincent's Hospital, Montclair, New Jersey.

3 Health Research Institute, Fairleigh Dickinson University, Madison, New Jersey.

Manuscript received 17 November 1967.




Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]