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Journal of Nutrition Vol. 94 No. 3 March 1968, pp. 369-375
Copyright © 1968 by American Society for Nutrition
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Effects of Cupric Ion and Digitonin in vitro on Erythrocytes and Liver Mitochondria from Essential Fatty Acid-deficient Rats

L. E. Trojan1 and R. M. Johnson

Institute of Nutrition and Food Technology and Department of Physiological Chemistry, The Ohio State University, Columbus, Ohio

Liver mitochondria and erythrocytes were isolated from essential fatty acid-deficient rats and the effect of cupric ion and digitonin on swelling and lysis was investigated. Both membranes were more resistant to the action of cupric ion than those isolated from rats fed a corn oil diet. In the presence of digitonin, deficient mitochondria swelled more rapidly and to a greater extent than the normal mitochondria. There appeared to be no difference in the susceptibility of normal and deficient erythrocytes to digitonin-induced lysis.

1 L. E. Trojan is the recipient of an Institute of Nutrition and Food Technology predoctoral traineeship. Supported in part by National Institutes of Health, U.S. Public Health Service, Training Grant no. 5 T1 ES-17, and U.S. Public Health Service Grant no. HE-05473.

Manuscript received 30 June 1967.




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