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Evidence of Malfunctioning Blood-Brain Barrier in Experimental Thiamine Deficiency in Rats^{1, 2,}

Department of Biochemistry, Vanderbilt University and the Research Division, Veterans Administration Hospital, Nashville, Tennessee

Labeling patterns in the free glutamic acid from brain tissue from rats injected with sodium pyruvate-2-¹⁴C indicate that the blood brain barrier is not functioning normally in thiamine deficiency. This alteration in selectivity permits pyruvic acid to enter the brain. The polyneuritis in deficiency, therefore, might result from altered metabolic pathways in the brain.

² Presented in part at the Fifty-first Annual Meeting of the Federation of the American Societies for Experimental Biology at Chicago, April, 1967.

Manuscript received 2 October 1967.