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Interrelationship of Dietary Glycine, Methionine and Vitamin E in the Rat

Division of Nutrition, Food and Drug Administration, Washington, D. C.

The ability of methionine and vitamin E, singly or in combination, to counteract the effects of an excessive intake of glycine was investigated. Weanling male rats were fed a 10 or 20% isolated soybean (soy) protein or an 11% lactalbumin diet for 4 weeks. Excess glycine (5% of diet) caused a 20% growth depression with lactalbumin and a 38% depression with soy only in the absence of dietary vitamin E. DL-Methionine or vitamin E prevented liver necrosis as determined histologically. The rats fed the vitamin E-free diet showed accentuation in tooth discoloration when glycine was added to the diet. Growth of rats fed a 10% soy diet with 0.9% methionine was significantly reduced when glycine was added to this diet. No difference in growth was observed with glycine in the presence of 1.8% methionine. Glycine partially alleviated the severe toxic effect of 3.6% methionine. Significant differences in liver and kidney weights were noted. Factors found to influence the response of the rat to excess glycine, in addition to vitamin E and methionine, were the protein level and source. A definite relationship between glycine and the level of dietary methionine is indicated.