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Cellular Response with Increased Feeding in Pituitary Dwarf Mice¹

Department of Pediatrics, Cornell University Medical College New York, New York

Studies were made to determine whether an observed increased weight, with increased caloric intake, in neonatal pituitary dwarf mice is accompanied by acceleration in the rate of cell division. Decreasing nursing litter size in pituitary dwarf mice increased weight and protein content of the entire animal and of certain organs with the exception of brain. DNA content, however, was not affected. Longevity of these animals was at least 2 times that of dwarfs raised in standard-size litters. These data are interpreted as demonstrating that increasing the total caloric intake of pituitary dwarf mice will result in increased total weight which is manifested by increased individual cell size without an increase in cell number. It is concluded that anterior pituitary hormones, in vivo, may play a role in DNA synthesis independent of their role in protein synthesis.

Manuscript received 13 September 1967.