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Abnormal Glucose Tolerance in Manganese-deficient Guinea Pigs^{1 ,2}

Department of Nutrition, University of California, Davis, California

The effects of low dietary manganese during pre- and postnatal development on glucose utilization of young adult guinea pigs is reported. Glucose tolerance tests were performed on deficient and control guinea pigs, using both oral and intravenous glucose administration. Deficient guinea pigs showed decreased utilization of glucose and in consequence had a diabetic-like glucose curve in response to glucose loading. Control animals and deficient guinea pigs, given dietary manganese equivalent in amount to that supplied control animals for 2 months, showed normal responses to glucose administration.

² Presented in part at the 51st annual meeting of the Federation of American Societies for Experimental Biology, Chicago, 1967.

Manuscript received 6 June 1967.