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Effects of Starch and Sucrose on the Serum Lipids of Dogs before and after Thyroidectomy¹

Jay Phillips Research Laboratory, Mount Sinai Hospital, and Department of Medicine and Physiological Hygiene, University of Minnesota, and Hennepin County General Hospital, Minneapolis, Minnesota

The effect of dietary starch and sucrose on the serum lipids was studied in 18 male dogs before and after total thyroidectomy. The diets consisted of a mixture of a low fat, low cholesterol dog food (55 parts) and either starch or sucrose (45 parts). The starch diet provided 47.6% of the calories as starch and the sucrose diet 49.0% of the calories as sucrose. The diets were fed for 2 weeks in a reversal design. Totál serum cholesterol, phospholipids and triglycerides were the same for the 2 dietary situations, before thyroidectomy. After thyroidectomy the sucrose diet caused serum triglyceride levels 13 mg/100 ml (± 4.3) higher than the starch diet. This difference was statistically significant (P = 0.006). The difference in triglyceride level between the sucrose and the starch diets was 11 mg/100 ml (± 5.2) higher after the thyroidectomy than before and this difference has a probability of chance occurrence of P = 0.05. The absence of a difference between the serum lipid levels caused by feeding either starch or sucrose to normal dogs may be related to the low cholesterol content of the diets used.

Manuscript received 10 August 1967.