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Journal of Nutrition Vol. 94 No. 1 January 1968, pp. 60-70
Copyright © 1968 by American Society for Nutrition
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Serum Lipid Responses in Dogs to Coconut and Sunflower Oils, before and after Thyroidectomy and with Thyroid Hormone Replacement1

Francisco Grande and Alvin L. Schultz

Jay Phillips Research Laboratory, Mount Sinai Hospital, Departments of Physiological Hygiene and Medicine, University of Minnesota, and Hennepin County General Hospital, Minneapolis, Minnesota

The effects on the serum lipids of feeding either coconut oil or sunflower oil (40% of the total calorie intake) was studied in dogs before and after thyroidectomy and with thyroid hormone replacement with D- and with L-thyroxine (4.0 mg and 0.3 mg/dog/day, respectively). The elevations of serum cholesterol and triglycerides caused by feeding coconut oil were significantly greater after thyroidectomy than before, but the elevation of serum phospholipids was smaller after thyroidectomy. The serum lipid changes produced by coconut oil after the thyroidectomy were comparable to those observed before when the thyroidectomized dogs were treated with the thyroid hormones. Feeding sunflower oil produced significant elevations of serum cholesterol and phospholipids, but no significant change of serum triglycerides. These responses were not affected by thyroidectomy or by thyroid hormone replacement. Administration of 4.0 mg/dog/day of D-thyroxine to thyroidectomized dogs fed a low fat diet decreased serum cholesterol concentration to the level observed before thyroidectomy. L-Thyroxine at the dose of 0.3 mg/dog/day had a smaller effect. The basal oxygen consumption of the thyroidectomized dogs was elevated by the hormonal treatment but the values attained were lower than those observed in normal dogs.

1 Supported by Public Health Service research Grant no. HE-09897 from the National Heart Institute, the John A. Hartford Foundation, Inc. New York and the Mount Sinai Hospital Research Fund.

Manuscript received 10 August 1967.




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