Journal of Nutrition

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Journal of Nutrition Vol. 94 No. 1 January 1968, pp. 6-12
Copyright © 1968 by American Society for Nutrition
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Autoradiographic Studies on the Distribution of Zinc-65 in Mice1

Bo Bergman and Rune Söremark

The Biophysical Laboratories at the University of Umeå, Umeå, Sweden and the Harvard University School of Dental Medicine, Boston, Massachusetts

The distribution of zinc in various organs and tissues was studied simultaneously at various periods after a single injection of labeled zinc. 63Zn as chloride in isotonic solution was injected intraperitoneally in adult mice, including pregnant females. The gross distribution patterns of labeled zinc were studied by means of whole-body autoradiography at various intervals after the injection of a single dose. The kinetics of zinc was generally found to be rapid. However, the uptake of zinc in the hard tissues and the central nervous system was slower than in other tissues. 63Zn was transported through the placenta into the fetus, and at 2 hours a high uptake was visible in the fetal bones and in the liver. Accumulation of zinc was found in liver, kidney, urinary bladder, lung tissues, pancreas, gastric and intestinal mucosa, hard tissues and cartilage. A relatively high concentration was also found in the retina and choroid of the eye, testes, lactating mammary glands, salivary and lacrimal glands, spleen, hair follicles and hair. The zinc level in blood, skeletal muscles, central nervous system and pituitary gland was low. After 24 hours and longer periods the concentration of zinc in the hard tissues dominated the distribution pattern.

1 This work was supported by Public Health Service Research Grant no. AM-08157 from the National Institute of Arthritis and Metabolic Diseases, by the United States Atomic Energy Commission contract AT(30-1)-3481, and by the Swedish Medical Research Council grant 23X-628.

Manuscript received 3 July 1967.




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