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Intestinal Absorption and Body Retention of ⁴⁷Ca in Rats: Evaluation of the method¹

Medical Service and Research, Veterans Administration Center, Los Angeles, California and Department of Medicine, University of California School of Medicine, Los Angeles, California

A method is described to study intestinal absorption and body retention of calcium in rats which requires the use of oral ⁴⁷Ca and monitoring of body radioactivity by a whole body counter. Extrapolation to zero time of the monoexponential portion of the body retention curve of ⁴⁷Ca was used to estimate net intestinal absorption. The slope of this curve provided an index of body retention of calcium. The validity of the estimate of intestinal absorption was confirmed by direct analysis of fecal, intestinal tract and carcass content of ⁴⁷Ca after oral administration. Quantitative data on intestinal absorption and body retention of ⁴⁷Ca after oral dose were obtained in various groups of normal rats of increasing weight and age. Growth and maturation had a depressing effect on both intestinal absorption and whole body retention of ⁴⁷Ca.

Manuscript received 28 February 1967.