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Effects of Dietary EDTA and Cadmium on Absorption, Excretion and Retention of Orally Administered ⁶⁵Zn in Various Tissues of Zinc-deficient and Normal Goats and Calves^{1 ,2 ,3}

Dairy Science Department, University of Georgia, Athens, Georgia

The effects of dietary EDTA (300 ppm) and cadmium (350 ppm) on absorption, excretion and tissue distribution of ⁶⁵Zn were determined following a single oral dosing in zinc-deficient and normal calves and goats. The feeding of EDTA had no significant effect upon fecal excretion or tissue distribution of ⁶⁵Zn. However, there was a marked increase in urinary ⁶⁵Zn excretion among the EDTA-fed animals which persisted throughout the experimental period. Dietary cadmium decreased absorption and tissue concentration of ⁶⁵Zn. When ⁶⁵Zn was calculated as percentage of absorbed dose most tissues of cadmium-fed animals contained amounts comparable to those of other animals. However, livers of cadmium-fed calves, but not goats, had more ⁶⁵Zn as a percentage of absorbed dose than livers of other animals. Cadmium had little effect on urinary excretion of ⁶⁵Zn. In general the effects of dietary EDTA and of cadmium in zinc-deficient animals were comparable to those in normal animals.

² This report is taken from a thesis submitted to the Graduate faculty of the University of Georgia by the senior author in partial fulfillment of the requirements for the Ph.D. degree.

³ Appreciation is extended to the Kraft Foods Company, Garland, Texas, for dried whole whey; to the Chas. Pfizer Company, Terre Haute, Indiana, for antibiotics and vitamins; to Hoffmann-LaRoche, Inc., Nutley, New Jersey, for the biotin; to Commercial Solvents, New York, for choline; to Merck and Company, Rahway, New Jersey, for pyridoxine and vitamin B₁₂; to Distillation Products, Inc., Rochester, New York, for d-a-tocopheryl acetate; to American Cyanamid, Princeton, New Jersey, for folic acid; to Abbott Laboratories, North Chicago, Illinois, for menadione; to Basic, Incorporated, Cleveland, for magnesium oxide; and to the Allied Chemical Company, Atlanta, Georgia, for urea.

Manuscript received 9 May 1967.