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Site and Rate of Active Transport of L-Lysine in the Intestine of the Fowl^{1 ,2}

Department of Animal Sciences, University of Maine, Orono, Maine

A study was made to determine whether the avian small intestine was capable of actively transporting L-lysine from the mucosal to the serosal surface against a concentration gradient; and if it was, whether the rate of transport varied along the length of the intestine. The rate of active transport of L-lysine across the intestinal wall of the fowl was determined at 6 levels of the small intestine; the upper and lower halves of the duodenum, of the jejunum and of the ileum. Transport rates were calculated both as the amount of lysine transported per unit weight of dried intestine and per length of live intestine. These data indicated no active transport of lysine by the duodenum but active transport by the jejunum and ileum. Based on weight, the jejunal and ileal levels transported 7.0 µmoles of lysine/g of dried intestine per hour. Based on length, the rate of active transport progressively decreased significantly from the upper jejunal to lower ileal regions of the small intestine. It was concluded that rates of L-lysine transported across the intestinal wall based on unit length represented true physiological differences between the various intestinal segments studied.

² This study was supported in part by grants from American Cyanamid, Princeton, New Jersey; Agway, Inc., Syracuse, New York; Merck and Company, Inc., Rahway, New Jersey; H. K. Webster Company, Lawrence, Massachusetts; and Wirthmore Feeds, Inc., Waltham, Massachusetts.

Manuscript received 5 May 1967.