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Effect of Protein Intake on the Development of Abnormal Tryptophan Metabolism by Men during Vitamin B₆ Depletion¹

Department of Foods and Nutrition, School of Home Economics, University of Wisconsin, Madison, Wisconsin

The effect of the level of dietary protein in the development of abnormal tryptophan metabolism in man during vitamin B₆ depletion was studied. Subjects fed a diet containing 54 g protein and 0.16 mg vitamin B₆ dialy developed abnormal tryptophan metabolism very slowly; after 40 days of vitamin B₆ depletion individual subjects excreted from zero to 29% of a 2-g loading dose of L-tryptophan as kynurenine, hydroxykynurenine, xanthurenic acid, kynurenic acid and acetylkynurenine. In contrast, subjects fed a diet containing 150 g of protein and 0.16 mg of vitamin B₆ daily excreted 29% of a 2-g loading dose of tryptophan as the 5 metabolites after 14 days of vitamin B₆ depletion. The post-tryptophan amounts of the tryptophan metabolites excreted by subjects given daily supplements of 1.5 mg pyridoxine were normal whether the protein intake was 54 or 150 g.

² Present address: Oregon State University, Corvallis, Oregon.

Manuscript received 20 March 1967.