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Effect of Dietary Carbohydrate on the Serum Protein Components of Two Strains of Rats

Human Nutrition Research Division, Agricultural Research Service, United States Department of Agriculture, Beltsville, Maryland

To determine the influence of dietary carbohydrate on serum protein components as resolved by moving boundary electrophoresis, BHE and Wistar-strain rats were fed high cholesterol diets containing sucrose, cornstarch or glucose. Carbohydrate-induced differences observed depended on age and strain and on state of fast. At 150 days fasted BHE rats fed glucose had pre-albumin (PA) more often in their sera, and lower albumin and ₁-globulin and higher -globulin concentrations than rats fed sucrose or cornstarch. At 350 days a high level of PA was observed when the diet contained sucrose. In nonfasted BHE rats fed sucrose, PA incidence was high at 150 and 350 days; it was significantly higher than with cornstarch at 150 days. Fasted Wistar rats, in contrast, had a higher PA incidence at 150 days with sucrose than with glucose but a low incidence regardless of carbohydrate at 350 days. In all except 350-day-old fasted rats, albumin and ₁-globulin concentration tended to be lower with cornstarch than with glucose. At 350 days, ₂- and ß-globulin levels were lower with starch than with glucose or sucrose when animals were fasted and higher when nonfasted. Regardless of diet or state of fast, PA level was directly related to level of serum noncholesterol lipids.