QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Godin, C. Search for Related Content PubMed PubMed Citation Articles by Godin, C.

Effect of Threonine on Tyrosine Metabolism of Rats Fed a Low Protein Diet

Department of Biology, University of Ottawa, Ottawa, Ontario, Canada

The alleviation of tyrosine toxicity obtained by the addition of threonine to a 3% tyrosine low protein diet was studied to determine the mode of action of threonine. Rats fed a 3% L-tyrosine and 1.25% L-threonine low protein diet had a lower plasma tyrosine concentration as compared with rats fed a 3% L-tyrosine low protein diet. Injection of these rats with L-tyrosine-U-¹⁴C indicated that the effect of threonine was not to increase the catabolism of tyrosine to ¹⁴CO₂ but to increase the excretion of radioactivity in the urine and the incorporation of radioactive tyrosine into plasma and liver proteins. In rats receiving an excess of tyrosine or threonine or both amino acids, the incorporation of DL-alanine-1-¹⁴C into tissue proteins was also increased over the control rats indicating a general stimulation of amino acid incorporation into proteins.