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Journal of Nutrition Vol. 92 No. 4 August 1967, pp. 435-442
Copyright © 1967 by American Society for Nutrition
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Plasma Lipids in Maternal and Fetal Rabbits Fed Stock and Peanut Oil-Cholesterol Diets1,2,

J. A. Sisson and E. J. Plotz

Departments of Pathology and Obstetrics and Gynecology, The Albany Medical College, Albany, New York

In 2 groups of pregnant rabbits, one fed a stock diet and the other fed a peanut oil-cholesterol diet, the maternal and fetal plasma levels of phospholipids, triglycerides, ester and free cholesterol were determined. The relative percentage of fatty acid composition of the phospholipid, nonesterified fatty acid, triglyceride and cholesterol ester fractions were also studied. The changes in maternal plasma lipid levels and fatty acid composition correlated well with the amount of fat and the fatty acid composition of the diets consumed by the 2 groups. The only significant change in the level of these plasma lipids in the fetus of the 2 groups was a small increase in the cholesterol ester level of the fat-cholesterol diet group. There were several alterations in the fatty acid composition of the fetal plasma lipids between the two dietary groups. Nearly one half of these were correlated with changes in the diets consumed by the maternal rabbits. Changes in fetal plasma fatty acid composition that correlated with the diets consumed were at least partly explained on a placental transport basis. The changes in fetal fatty acid composition that were not correlated with the diet were probably due to indirect dietary-induced changes in fetal lipid metabolism, possibly through multiple step pathways.

1 This investigation was supported by Public Health Service Research Grant no. HD-1462 from the National Institute of Child Health and Human Development.

2 Presented in part at the Annual Meeting of the American Institute of Nutrition, Chicago, 1967.

Manuscript received 21 February 1967.




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