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Effects of Selenate, Selenite and Tellurite on the Growth and Early Survival of Mice and Rats¹

Department of Physiology, Dartmouth Medical School, Hanover, New Hampshire and Brattleboro Memorial Hospital, Brattleboro, Vermont

To evaluate long-term effects of low doses of selenium and tellurium on the growth and survival of small mammals, rats numbering 102 or more were given 2 µg/ml selenium in drinking water, either as Na₂SeO₂ or Na₂SeO₄, and 2 µg/ml tellurium as Na₂TeO₃. Selenate and tellurite were well-tolerated. Selenite was not, males dying rapidly at early ages and females less so. Growth was depressed. Mice numbering 108 or more were given selenite or tellurite, 2 µg/ml of the element in drinking water. Both elements were tolerated. Growth was enhanced in males given selenite, and somewhat depressed in females. At 15 months of age male mice given tellurite showed some increased mortality and body weights were less than those of controls. Species of animal, sex and valence state of selenium were of importance in evaluating effects of this trace element.

² Present address: 9 Belmont Avenue, Brattleboro, Vermont 05301.

Manuscript received 27 January 1967.

This article has been cited by other articles:

				O.E. Olson Selenium Toxicity in Animals with Emphasis on Man International Journal of Toxicology, January 1, 1986; 5(1): 45 - 70. [Abstract] [PDF]