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Journal of Nutrition Vol. 92 No. 3 July 1967, pp. 331-333
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Biosynthesis of Ascorbic Acid in the Acouchi and Agouti1

Norma J. Yess and D. M. Hegsted

Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts

The biosynthesis of ascorbic acid has been studied in the acouchi and agouti, 2 members of the Hystricomorph sub-order of Rodentia. Unlike the guinea pig, a member of this same sub-order, the acouchi and agouti are able to produce endogenous ascorbic acid, as demonstrated by studies of homogenates of livers obtained from these animals. Ingestion of a vitamin C-deficient diet by the agoutis produced none of the classical signs of scurvy. In view of these findings, it would be of interest to study other, closely related animals to determine whether they possess the ability to synthesize the vitamin.

1 Supported in part by Public Health Service Research Grant no. 5-K6-AM-18,455 from the National Institute of Arthritis and Metabolic Diseases, and the Fund for Research and Teaching, Department of Nutrition, Harvard School of Public Health.

Manuscript received 18 February 1967.




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