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Absorption, Excretion, and Retention of Orally Administered Zinc-65 in Various Tissues of Zinc-deficient and Normal Goats and Calves^1,2,

Dairy Science Department and School of Veterinary Medicine, University of Georgia, Athens, Georgia

Absorption, excretion and tissue distribution of ⁶⁵Zn was determined following oral dosing in zinc-deficient and normal calves and goats. In the livers, level of ⁶⁵Zn was higher at 2 days than at later times. In some tissues, including hair, bone and muscle, the ⁶⁵Zn concentration increased with time while in others the level reached a peak between 2 and 28 days after oral dosing. The tissues of the zinc-deficient animals held the ⁶⁵Zn more tenaciously than those of the control animals. Fecal excretion of ⁶⁵Zn reached a peak the third day after dosing and declined thereafter. ⁶⁵Zn excretion via feces was higher for control than zinc-deficient animals. Apparent absorption was very high exceeding 80% for some treatments. These high absorption values are attributed to several factors including semipurified diets containing very low levels of zinc and are a reflection of mechanisms resulting in homeostatic conservation of the zinc.

² Appreciation is extended to the Kraft Foods Company, Garland, Texas, for the dried whole whey; to the Chas. Pfizer Company, Terre Haute, Indiana, for antibiotics and vitamins; to Hoffmann-LaRoche, Inc., Nutley, New Jersey, for the biotin; to Merck, Sharp and Dohme Company, Rahway, New Jersey, for pyridoxine; to the Commercial Solvents Company, New York, for the choline; to Distillation Products Industries, Rochester, New York, for d-a-tocopheryl acetate; to Basic, Inc., Cleveland, for the magnesium oxide; to the Allied Chemical Company, Atlanta, Georgia, for the urea; to the American Cyanamid Company, Princeton, New Jersey, for chlortetracycline; and to the Smith-Douglas Company, Norfolk, Virginia, for the defluorinated rock phosphate.

Manuscript received 29 August 1966.