Journal of Nutrition

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Journal of Nutrition Vol. 92 No. 1 May 1967, pp. 30-42
Copyright © 1967 by American Society for Nutrition
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The Relationship of Ca and P Nutrition during Adult Life and Osteoporosis in Aged Mice1

B. G. Shah2, G. V. G. Krishnarao and H. H. Draper

Division of Nutritional Biochemistry, Department of Animal Science, University of Illinois, Urbana, Illinois

The influence of Ca and P intake throughout adult life on bone and soft tissue calcification and the incidence of osteoporosis at senescence was investigated in mice. Animals were maintained from 10 to 26 months of age with diets ranging from 0.1% to 2.4% in Ca and from 0.05% to 1.2% in P. When the Ca:P ratio was 2:1, increases in dietary Ca were associated with increments in ash content, cortical thickness, parabolic index and breaking load of the femur. When the Ca:P ratio was 1:1, these parameters were depressed and unresponsive to increases in dietary Ca. The highest values for bone mineral were obtained by feeding 1.2% Ca and 0.6% P in the diet and the lowest by feeding 1.2% Ca and 1.2% P. Aging was accompanied by a porosity of the tibial cortex which was unrelated to the level of dietary Ca. The results show that the cortical thickness and mineral content of the femurs of aged mice are depressed by chronic consumption of a diet in which there is either a suboptimal concentration of Ca or an adverse ratio of Ca:P when the Ca level is adequate. Porosity of the tibial cortex at senescence is not related to the level of Ca intake during adult life, but is enhanced when Ca and P are consumed in a 1:1 as opposed to a 2:1 ratio.

1 This study was carried out with the aid of Public Health Service Research Grant no. AM-07052 from the National Institute of Arthritis and Metabolic Diseases.

2 Present address: Nutrition Division, Food and Drug Research Laboratory, Tunney's Pasture, Ottawa 3, Ontario, Canada.

Manuscript received 10 December 1966.




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