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Effect of Environmental Temperature on Fatty Livers Produced by Various Hepatotoxic Agents in Rats¹

Defence Research Medical Laboratories, Toronto, Ontario, Canada

The effect of a low environmental temperature on the development of fatty infiltration of the liver after various treatments was studied. Rats, housed at environmental temperatures of 22° and 4° for 14 days, were treated with a cholinedeficient diet, carbon tetrachloride, ethionine, 4-aminopyrazolopyrimidine, orotic acid, or ethanol. Fatty liver was produced by each of the treatments in the rats housed at 22°. A temperature of 4° prevented the development of fatty liver in the rats fed the choline-deficient diet in confirmation of previous results but had no effect on fatty livers caused by the administration of carbon tetrachloride, ethionine, 4-aminopyrazolopyrimidine, and orotic acid. A partial lipotropic effect of cold exposure was observed in the animals treated with ethanol.

Manuscript received 2 November 1966.