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Journal of Nutrition Vol. 92 No. 1 May 1967, pp. 133-137
Copyright © 1967 by American Society for Nutrition
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Amino Acid Imbalance and Liver Glycogen Changes in Rats Fed Glycine1

S. V. Hunter2, L. E. Laastuen and W. R. Todd

Department of Biochemistry, University of Oregon Medical School, Portland, Oregon

The relation of dietary additives to the maintenance of liver glycogen in rats under conditions of stress was studied. Previous work established that rats prefed a semipurified diet containing 10% glycine maintained liver glycogen at much higher levels after a cold water swim-stress and following recovery from the stress than animals prefed the diet without added glycine. In the present study amino acid analyses of blood serum demonstrated a sharp decrease in L-tyrosine of glycine-fed rats. Feeding L-tyrosine with the glycine diet caused increased blood levels of this amino acid and the high level of liver glycogen due to glycine feeding was abolished. D-Tyrosine fed in the glycine diet did not have this effect on liver glycogen, whereas L-phenylalanine had an effect on liver glycogen similar to that of L-tyrosine. It is suggested that the elevated tissue levels of glycine cause an overloading of tissue cell amino acid transport systems. As a result some amino acids are unavailable for protein synthesis and are deaminated, leaving the carbon chains of several available for utilization in carbohydrate formation.

1 This investigation was supported in part by Public Health Service Research Grant no. AM-04336 from the National Institute of Arthritis and Metabolic Diseases.

2 This work represents parts of a thesis by S. V. Hunter submitted to the University of Orgeon Medical School in partial fulfillment of the requirements of the Ph.D. degree. Present address: Providence Hospital, Portland, Oregon.

Manuscript received 3 January 1967.




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