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Lack of Effect of Thiamine Deficiency on Oxidation of Methylglyoxal-¹⁴C in the Rat

General Medical Research Laboratory, Veterans Administration Center, Togus, Maine

The effect of thiamine deficiency on the in vivo oxidation of methylglyoxal-1,3-¹⁴C and methylglyoxal-2-¹⁴C to ¹⁴CO₂ was studied in the rat. The rapidity with which the ¹⁴C label appeared in the expired CO₂ favors the interpretation that methylglyoxal metabolism is not impaired in the thiamine-deficient rat. The appearance of ¹⁴C label in liver glycogen and urine keto acids also indicated that it rapidly entered the classical metabolic pathways. The data suggest a rapid transformation of methylglyoxal to pyruvate and entrance into the Krebs cycle.