Journal of Nutrition

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Journal of Nutrition Vol. 91 No. 3_Suppl March 1967, pp. 353-357
Copyright © 1967 by American Society for Nutrition
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Water Fluoridation: Effect on bone fragility and skeletal calcium content in the rat1

Paul D. Saville

The Hospital for Special Surgery, affiliated with The New York Hospital-Cornell University Medical College, New York, New York

The calcium content of the axial skeleton and the forelimb is a linear function of body weight and is increased in rats when they drink water containing 20 ppm of fluorine in the form of sodium fluoride, but not in the hindlimb nor when they drink water containing 2 or 5 ppm of fluorine. Breaking force of the humerus and femoral shaft is a linear function of body weight and is unaffected by water fluoridation up to a concentration of 20 ppm.

1 This investigation was supported in part by Public Health Service Research Grant no. 5 SO1 FR-05495 from the General Support Branch Division of Research Facilities and Resources; U.S.P.H.S. Graduate Training Grant T1 AM-5414 from the National Institute of Arthritis and Metabolic Diseases, and the Whitehall Foundation.

Manuscript received 23 March 1966.




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