Journal of Nutrition

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Journal of Nutrition Vol. 91 No. 3_Suppl March 1967, pp. 319-323
Copyright © 1967 by American Society for Nutrition
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Effect of Vitamin D3 on the in vitro Transport of Calcium by the Chick Intestine1

S. Hurwitz2, H. C. Harrison and H. E. Harrison

Department of Pediatrics, The Johns Hopkins University School of Medicine and Baltimore City Hospitals, Baltimore, Maryland

The effect of vitamin D3 treatment of the chick on concentrative transport of calcium by intestinal loops in vitro, on intestinal permeability to calcium in vitro and on calcium efflux from tied-off intestinal loops in situ was determined. Concentrative transport of calcium in vitro could not be demonstrated when chick intestine was incubated in K-H buffer (Na = 145 mM) but was observed when everted intestinal loops were incubated in a low sodium buffer (Na = 26 mM). In this low sodium medium, concentrative transport of calcium was observed only in the ileal segment and was greatly enhanced by vitamin D3 treatment of the chick. Vitamin D3 treatment was also shown to increase the permeability to calcium of the intestinal loop in vitro. In the in vitro preparations calcium was not transferred across the wall of the duodenum. In situ, however, the most rapid efflux of calcium occurred in the duodenal loop and was greatly enhanced by vitamin D treatment.

1 Supported by Public Health Service Research Grant no. AM-00668 from the National Institute of Arthritis and Metabolic Diseases.

2 Permanent address: The Volcani Institute of Agricultural Research, Rehovot, Israel.

Manuscript received 17 September 1966.


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R. A. Corradino and R. H. Wasserman
Vitamin D3: Induction of Calcium-Binding Protein in Embryonic Chick Intestine in vitro
Science, May 14, 1971; 172(3984): 731 - 733.
[Abstract] [PDF]


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