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Journal of Nutrition Vol. 91 No. 3_Suppl March 1967, pp. 303-306
Copyright © 1967 by American Society for Nutrition
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Mechanism of the Effect of Retinoic Acid and Squalene on Vitamin K Deficiency in the Rat1

John T. Matschiner, J. M. Amelotti and E. A. Doisy, Jr.

Department of Biochemistry, St. Louis University School of Medicine, St. Louis, Missouri

The anticoagulant effect of squalene and retinoic acid was studied in adult male rats fed purified diets deficient in vitamin K. Both appear to inhibit absorption of vitamin K although possibly by different mechanisms. The requirement for vitamin K increased with a dietary increase of squalene but maximal action of retinoic acid was easily obtained and further ingestion of vitamin A did not affect prothrombin levels. The requirement for vitamin K in rats fed 0.5% squalene or 50 IU of retinoic acid/g of diet was about 9 µg/day which resembles the requirement in germfree rats. On this basis indigestible oils and retinoic acid may be useful agents for the production of "simple" vitamin K-deficiency in mammalian species.

1 These studies were supported in part under grant no. DA-MO-49-193-62-G41 from the Office of the Surgeon General, Department of the Army and Public Health Service Research Grant no. AM-09909 from the National Institute of Arthritis and Metabolic Diseases. The opinions expressed are those of the authors and not necessarily those of the Department of the Army.

Manuscript received 11 October 1966.




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