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Effect of Chronic Ethanol Feeding on Rat Liver Phospholipid^{1, 2,}

Department of Pathology, San Francisco General Hospital, University of California School of Medicine, San Francisco, California

Determinations of liver phospholipid concentration and composition were made in experiments to investigate the effect of chronic ethanol ingestion on liver phospholipid metabolism in the rat. Each ethanol-fed animal was grouped with a control animal pair-fed the basal diet plus sucrose and a control animal fed the basal diet ad libitum. Both male and female animals fed ethanol developed increased concentrations of liver phospholipid; the increment in the males was greater than that in the females. Quantitative two-dimensional thin-layer chromatography of the phospholipid fractions showed an increase in lysolecithin and phosphatidyl ethanolamine in the ethanol-fed animals, whether calculated on the basis of phospholipid concentration or total liver content. The increase in lysolecithin, a membrane-lysing agent, may be relevant to alterations reported in experimental and clinical chronic alcoholism.

² Presented in part at the 50th Annual Meeting of the Federation of American Societies for Experimental Biology, Atlantic City, New Jersey, 1966 (French, S. W. 1966 Chronic ethanol feeding and rat liver phospholipid content. Federation Proc., 25: 478 (abstract)).

Manuscript received 18 July 1966.

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