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Effect of Calcium and Gossypol on the Performance of Swine and on Certain Enzymes and Other Blood Constitutents^1,2,

Institute of Nutrition of Central America and Panama (INCAP), Guatemala, Central America

The effect of calcium and iron supplementation on gossypol toxicity, as measured by weight gains and changes in certain blood constituents, was studied in swine. Groups of 6 Duroc-Jersey pigs each were fed rations containing 2 levels of gossypol supplemented with 2 levels of calcium hydroxide. The protein source in the ration was cottonseed meal for the experimental groups and soybean meal for the control groups. Additional groups received the higher level of gossypol supplemented with ferrous sulfate, by itself or with the higher level of calcium used. Weight gains at 15 weeks showed that simultaneous supplementation with calcium and iron resulted in weight gains similar to those obtained with the control rations. Blood samples taken at zero, 7 and 15 weeks showed that hemoglobin and hematocrit values were significantly decreased, and glutamic-oxalacetic transminase was significantly increased by gossypol feeding. Lactic dehydrogenase, leucine amino peptidase, and aldolase in the serum were not significantly affected by gossypol.

² INCAP Publication I-398.

Manuscript received 24 June 1966.

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