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Observations on Respiratory Decline in the Prenecrotic Phase of Dietary Liver Necrosis¹

Istituto di Patologia Generale dell'apos;Università di Bologna, Bologna, Italy

The capacity to oxidize succinate was studied with liver mitochondria, homogenates or slices from rats maintained with commercial diets or with semipurified diets with or without addition of vitamin E or sodium selenite. A decline in the oxidation rate was observed with all systems in vitamin E-deficient, selenium-deficient animals, and in some instances in rats fed commercial diets. The decline was prevented by administration of large amounts of vitamin E. Dietary selenite prevented decline in mitochondria, but not in homogenates or slices. The significance of respiratory decline as a possible specific lesion of the latent phase of dietary liver necrosis is discussed.

Manuscript received 22 April 1966.