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Journal of Nutrition Vol. 90 No. 4 December 1966, pp. 361-363
Copyright © 1966 by American Society for Nutrition
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Functional and Allometric Descriptions of the Liver and Small Intestine in Genetically Obese Mice1

Henry J. Binder2, Teodoro Herskovic, Howard M. Spiro and Richard P. Spencer

Departments of Medicine and Radiology, Yale University School of Medicine, New Haven, Connecticut

To assess intestinal activity in mice with the hereditary obese hyperglycemic syndrome, the small gut was studied by means of histochemistry, as well as the transport of 10-3 M glucose and 5 x 10-6 M L-methionine against a concentration gradient in vitro. In addition, the weight of the intestine was determined at nine and eleven weeks of age. There was no difference in the histochemical reactions of the gut between affected animals and their normal littermates. There was also no impairment of in vitro transport of the 2 nutrients. While the small gut of the obese animals weighed more than that of controls, the weight was correctly predicted by the allometric relationship on the basis of their increased body weight. The weight of the liver in the hereditary obese hyperglycemic mice was considerably greater than predicted by the allometric relationship.

1 Supported by Public Health Service Research Grant no. CA-06519 from the National Institute of Cancer, and nos. AM-09429 and AM-08870 from the National Institute of Arthritis and Metabolic Diseases.

2 Recipient of a Special Fellowship from the Public Health Service (1 F 3 AM-28399).

Manuscript received 30 June 1966.




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