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Alterations in the Metabolism of 2-¹⁴-C-Thiazole-labeled Thiamine by the Rat Induced by a High Fat Diet or Thyroxine¹

Division of Nutrition, Department of Biochemistry, Vanderbilt University Medical School, Nashville, Tennessee

This study was designed to test the hypothesis that dietary fat "spares" thiamine by reducing its metabolic destruction. Fourteen adult rats of the Sprague-Dawley strain, of similar nutritional backgrounds, were fed a "low" fat (11% calories from fat) diet and injected daily with 50 µg 2-¹⁴C-thiazole-labeled thiamine for 8 weeks. For 10 days, seven of the group were then fed a "high fat" diet (63% calories from fat) isocalorically with the remainder of the group that was continued on the "low-fat" regimen. Daily injections of radioactive thiamine were continued during this period. The rats fed the high fat diet excreted significantly more radioactive thiamine in the urine but significantly less ¹⁴CO₂ than did the controls. In a similar study, the administration of 20 µg of thyroxine daily to rats fed the "low fat" diet enhanced the excretion of ¹⁴CO₂ but did not alter the excretion of urinary radioactivity.

² Present address: Imperial Iranian Army Nutrition Committee, Army Medical Department, Aziz Khan Crossroad, Hafez-Avenue, Tehran, Iran.

Manuscript received 23 April 1966.