Journal of Nutrition

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Journal of Nutrition Vol. 90 No. 2 October 1966, pp. 141-147
Copyright © 1966 by American Society for Nutrition
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Comparative Effects of Dihydrotachysterol2 and Dihydrotachysterol3 in Chicks1

H. Bruce Bosmann and Philip S. Chen, Jr.

Department of Radiation Biology and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, New York

Crystalline dihydrotachysterol2 (DHT2) was compared with vitamins D2 and D3 and with dihydrotachysterol3 (DHT3) over a wide dose range in chicks fed a rachitogenic diet. Effects on mineral metabolism were evaluated by following changes in serum calcium and phosphorus levels and in percentage bone ash. Both DHT2 and DHT3 possessed potent antirachitic and toxic actions, with a very narrow therapeutic range. DHT3 was only very slightly more potent than DHT2 in chicks in marked contrast with the tenfold potency difference of the parent molecules, vitamins D3 and D2, in this species.

1 This paper is based on work performed under contract with the United States Atomic Energy Commission at the University of Rochester Atomic Energy Project, Rochester, New York, and was supported in part by a Public Health Service Fellowship (817-01) from the National Institute of General Medical Sciences to H. B. Bosmann.

Manuscript received 12 May 1966.




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