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Experiments with a new type of antirachitic substance. Lester Yoder, B. H. Thomas and Malcolm Lyons, Iowa Agricultural Experiment Station, Ames Iowa.

Recently Yoder¹ reported that an antirachitic derivative, namely, cholesterilene sulfonic acid, can be prepared from cholesterol without resorting to irradiation. We have found in working with this derivative and certain of its salts that their effects on intestinal reaction, iron reduction and calcification are very similar to those of viosterol.

The calcium salt of cholesterilene sulfonic acid has been repeatedly prepared and has been found to possess the same constant composition and antirachitic potency. Sulfonic acids prepared in the same manner from a variety of synthetic alcohols have failed to exhibit any antirachitic activity.

In view of the wide differences in the efficacy of cod liver oil and viosterol as antirachitics for chicks, calcium cholesterilene sulfonate was compared with these commonly employed supplements. Two such tests have demonstrated that chicks are able to utilize calcium cholesterilene sulfonate more efficiently than cod liver oil and much more so than viosterol. For example, the tibiae of chicks fed rations containing 2 rat units of cod liver oil or 50 rat units (Steenbock) of viosterol per 100 gm. of ration contained practically the same percentage of ash as those of the negative control group; namely, 28.7 per cent. However, chicks similarly fed rations containing 2 and 50 rat units (Steenbock) of calcium cholesterilene sulfonate yielded bones which ashed practically the same as the positive control group; namely 47.3 per cent.