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Journal of Nutrition Vol. 89 No. 4 August 1966, pp. 501-504
Copyright © 1966 by American Society for Nutrition
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Amino Alcohols and Methyl Donors in Rats Fed Low Choline Diets Containing Added Cholesterol1

Melvin D. Chaplin and Dwight J. Mulford

Department of Biochemistry, University of Kansas Medical Center, Kansas City, Kansas

A study was carried out to elucidate the effects of ethanolamine and its N-methyl derivatives and of the methyl donors in weanling male rats consuming low choline diets containing added cholesterol for 7 days. The diets contained 36% casein. As the cholesterol level was increased in the diet the liver fat increased and there was an increased in the incidence and severity of hemorrhagic kidneys. The cholesterol effect was prevented by adding the N-methyl derivatives of ethanolamine but was only partially prevented by ethanolamine at the levels of ethanolamine studied. Methionine and betaine prevented the occurrence of kidney lesions but had little effect on the liver fat. Feeding the methyl donors and ethanolamine together in the diet containing added cholesterol was highly effective in preventing liver fat accumulation.

1 This investigation was supported by Public Health Service Research Grant no. 5 RO1 AM07054 from the National Institute of Arthritis and Metabolic Diseases and by Training Grant no. 2 T 1 GM 492 from the National Institutes of Health.

Manuscript received 25 February 1966.




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