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Initiation of Glucose 6-Phosphatase Adaptation in the Rat¹

Department of Physiological Sciences, University of California, Davis, and Department of Biochemistry, University of Wisconsin, Madison

Rats trained to eat for only one hour each day were used to investigate the time required for increases in hepatic glucose 6-phosphatase activity to occur in response to ingestion of high sucrose and high protein diets. Glucose 6-phosphatase activity per unit of body weight decreased during the first few hours after the rats had eaten, regardless of the diet consumed. After 4 hours glucose 6-phosphatase activity of rats fed high protein or high sucrose diets was greater than that of rats fed a 25% casein diet containing dextrin. There was a continuous increase in liver glycogen concentration and relative size in all groups up to 8 hours after they had eaten. Hydrocortisone injection produced a marked increase in liver glycogen concentration and relative size of rats within 8 hours after injection, but had no effect on the glucose 6-phosphatase activity per unit of body weight 8 or 12 hours after injection.

Manuscript received 5 April 1966.