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Pantothenic Acid Deficiency in the Mink^1,2,

Departments of Animal Husbandry and Bacteriology and Pathology, Cornell University, Ithaca, New York and U. S. Fur Animal Experiment Station, ARS, Ithaca, New York

Ten female and 230 male kits were used to study the need for pantothenic acid by growing mink. Three trials were conducted using purified diets with ad libitum and equalized paired-feeding techniques. The minimal pantothenic requirement for growth was found to be 5 mg of calcium pantothenate/kg of diet, whereas 8 mg/kg of diet were required for optimal performance. Anorexia and reduced serum cholesterol were early responses to hypovitaminosis. The gross pathological findings were diarrhea, cachexia, and dehydration with hemorrhagic gastric ulcers and specific starvation lesions.

² These studies were supported in part by a grant from the Mink Farmers' Research Foundation, Milwaukee, Wisconsin.

³ Department of Animal Science, Cornell University, Ithaca, New York.

⁴ Present address: School of Public Health, Harvard University, Cambridge, Massachusetts.

⁵ U. S. Fur Animal Experiment Station, ARS, Ithaca, New York.

⁶ Department of Bacteriology and Pathology, Cornell University, Ithaca, New York.

Manuscript received 15 March 1966.