QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Stewart, C. N. Articles by Dakshinamurti, K. Search for Related Content PubMed PubMed Citation Articles by Stewart, C. N. Articles by Dakshinamurti, K.

Effect of Biotin Deficiency on Escape and Avoidance Learning in Rats¹

Department of Psychology, Franklin and Marshall College and Research Institute, St. Joseph Hosptial, Lancaster, Pennsylvania

The effect of biotin deficiency on the ability of Sprague-Dawley rats to acquire conditioned avoidance and escape reactions was investigated. Avoidance learning was impaired with both 5.0-second and 2.0-second intervals between conditional and unconditional stimuli. Escape learning was not affected, suggesting that the defect in avoidance learning was not due to motor impairment. Behavioral and biochemical evidence suggests that effects of the deficiency on the central nervous system may be expected.

² Present address: Department of Biochemistry, University of Manitoba, Winnipeg 3, Manitoba, Canada.

Manuscript received 10 December 1965.