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Journal of Nutrition Vol. 88 No. 3 March 1966, pp. 273-283
Copyright © 1966 by American Society for Nutrition
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Chronic Skin Homograft Rejection in Vitamin B6-deficient Mice1

Nicholas G. Herr2 and David B. Coursin2

Research Institute, St. Joseph Hospital and Department of Biology, Franklin and Marshall College, Lancaster, Pennsylvania

A study was made of the effects on skin homograft survival times in strain C57 mice given a diet deficient in pyridoxine (vitamin B6). The pyridoxine-deficient mice showed a prolonged survival time for the homografts and exhibited a chronic homograft rejection pattern. The cellular details of this chronic rejection are presented in a series of photomicrographs which illustrate how the chronic type differs from the usual acute homograft reaction.


1 Supported in part by Public Health Service Research Grant no. B-1929 from the National Institutes of Health, and funds from the National Vitamin Foundation.

2 N. G. Herr, present address: School of Medicine, University of Pennsylvania, Philadelphia, Pa.; D. B. Coursin, St. Joseph Hospital, Lancaster, Pa.

Manuscript received 29 November 1965.





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