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Journal of Nutrition Vol. 88 No. 3 March 1966, pp. 267-272
Copyright © 1966 by American Society for Nutrition
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Glucose Oxidation and Glycogen Metabolism in Fluoride-fed Rats1,2,

E. J. Zebrowski3 and J. W. Suttie

Department of Biochemistry, University of Wisconsin, Madison, Wisconsin

Some of the metabolic fates of glucose were investigated in control and fluoride-fed animals. There was no significant difference in the ability of animals ingesting 450 ppm F to oxidize glucose to carbon dioxide. No relationship was observed between fluoride ingestion and the percentage liver glycogen observed, and blood glucose levels were not altered by fluoride ingestion. Radioactive glucose was incorporated into liver glycogen of both intact control animals and into liver slices from control animals at a faster rate and reached a higher level than was observed in the fluoride-fed rats. Glycogenolysis was greater in liver slices prepared from control animals. The extent of glycogenolysis was independent of the pre-incubation glycogen level which was not altered by the dietary treatment. The addition of fluoride to liver slices from control animals had no effect on the degree of glycogenolysis, and it was concluded that fluoride acts to depress the turnover of liver glycogen, in an indirect manner rather than by direct enzyme inhibition.

1 Supported in part by a research grant from the Aluminum Company of America, the Aluminum Company of Canada Ltd., the Kennecott Copper Corporation, the Monsanto Chemical Company, the Ormet Corporation, the Tennessee Valley Authority, the Victor Chemical Works, Reynolds Metals Company, the Kaiser Aluminum and Chemical Corporation, the Harvey Aluminum Company, the U. S. Steel Corporation of Delaware, and the Tennessee Corporation.

2 A preliminary report of this work was presented at the 48th Annual Federation meetings, Atlantic City, April, 1964.

3 Present address: Department of Oral Biology, Dental College, University of Manitoba, Winnipeg 3, Manitoba. Canada.

Manuscript received 24 September 1965.




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