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Journal of Nutrition Vol. 88 No. 3 March 1966, pp. 255-260
Copyright © 1966 by American Society for Nutrition
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Effects of Dietary Calcium upon Lipid Metabolism in Mature Male Rats Fed Beef Tallow1

A. I. Fleischman2, H. Yacowitz3, T. Hayton4 and M. L. Bierenbaum5

Health Research Institute, Fairleigh Dickinson University, Madison, New Jersey and the Atherosclerosis Research Group, St. Vincent's Hospital, Montclair, New Jersey

In an attempt to elucidate the hypocholesterolemic and hypotriglyceridemic action of dietary calcium, 24 mature male Holtzman strain albino rats were fed a corn-soya ration containing 18% added beef tallow and 2% added cholesterol for 21 days. Dietary calcium was varied at 0.08, 0.2 and 1.2% of diet. Blood lipids decreased with increasing dietary calcium, the major decrease occurring at the 0.2% calcium level. Some tissue lipids decreased; none increased. Fecal lipids did not significantly increase at the 0.2% calcium level, but did at the 1.2% level. Fecal fatty acids became progressively more saturated with increasing calcium intake, but the preferential excretion of saturated fatty acids did not appear to be sufficient to alter significantly the blood fatty acids. Fecal bile acids significantly increased at the 0.2% calcium level, with no additional increase at the 1.2% calcium level. These results suggest that the lowering of blood cholesterol by increase in dietary calcium is mediated in part by increased excretion of bile acids.

1 This work was supported by Public Health Service Research Grant no. H-5905 from the National Heart Institute, and by a grant from the Deering Milliken Foundation.

2 Supervising Biochemist, Atherosclerosis Research Group, and Research Associate, Health Research Institute.

3 Research Associate, Health Research Institute, and Consultant in Nutrition, Atherosclerosis Research Group.

4 Associate Professor, Statistics, Rutgers, the State University, and Supervising Statistician, Atherosclerosis Research Group.

5 Project Director, Atherosclerosis Research Group, and Consultant in Medicine, Health Research Institute.

Manuscript received 23 October 1965.




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