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A Study of Some Enzyme Systems in Livers of Rats after Prolonged Ingestion of Alcohol¹

School of Pharmacy, American University of Beirut, Beirut, Republic of Lebanon

In an effort to determine the reason for the consistently greater quantities of hepatic -ketoglutaric acid in alcohol-treated rats, 3 enzyme systems which lead to this acid were measured, namely, isocitric (ICDH), succinic (SDH) and glutamic (GDH) dehydrogenases. After an experimental period of 28 weeks, the activities of these enzymes were determined in the livers of control rats and also of rats given a 20% solution of ethanol as the sole drinking fluid. Both groups were fed an adequate purified diet. The results indicated a significant increase in activities for both ICDH and GDH. In contrast, SDH increased only slightly. Based on these observations, a possible explanation was offered for the increase in the hepatic -ketoglutarate level of the alcohol-treated rats. Moreover, it was postulated that the increase in both enzymes might have been due to an adaptive mechanism induced by alcohol to offset the insult of alcohol on the liver.

Manuscript received 9 August 1965.