Journal of Nutrition

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Journal of Nutrition Vol. 87 No. 4 December 1965, pp. 477-484
Copyright © 1965 by American Society for Nutrition
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Effect of Alcohol on Growth, Bone Density and Muscle Magnesium in the Rat1

Paul D. Saville and Charles S. Lieber2

Bone Metabolism Laboratories of the Hospital for Special Surgery Affiliated with the New York Hospital — Cornell University Medical College, New York and the Liver Disease and Nutrition Unit of the Second (Cornell) Medical Division, Bellevue Hospital and the Department of Medicine, Cornell University Medical College, New York

A group of rats fed a nutritionally adequate diet were compared with their pair-fed littermate controls that had the same diet but with ethanol isocalorically replacing sucrose. The ethanol-fed rats developed fatty liver, as described elsewhere, and although the growth constant was unchanged, it was calculated that the maximal weight they could attain if time were extended indefinitely was less than that of the controls. The density of the tibiae and femora was found to be a linear function of the animal's weight and the decrease in density of these bones in the ethanol-fed animals could be explained by the difference in weight between the 2 groups of animals. Muscle magnesium was not significantly different in the ethanol-fed and control animals.

1 Supported by The John Lindsley Fund, Public Health Service General Support, Public Health Service Training Grant no. AM-5414 from the Institute of Arthritis and Metabolic Diseases, the Whitehall Foundation, the Evelyn Sharp Foundation, and Public Health Service Research Grant no. AM-06284 from the Institute of Arthritis and Metabolic Diseases.

2 Recipient of Public Health Service Research Career Development Award K3AM22590.

Manuscript received 12 July 1965.




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