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Journal of Nutrition Vol. 87 No. 2 October 1965, pp. 161-167
Copyright © 1965 by American Society for Nutrition
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Metabolic Response to Realimentation Following Chronic Starvation in the Adult Male Rat1

Bruce E. McDonald2 and B. Connor Johnson

Division of Nutritional Biochemistry, Department of Animal Science, University of Illinois, Urbana, Illinois

Changes in liver weight, liver glycogen and lipid concentrations, and certain hepatic enzyme activities were studied during realimentation of adult male rats previously starved 9 to 12 days. Liver weight increased nearly twofold during the first 48 hours of refeeding and then declined to normal at 96 hours post-refeeding. Composition of the hepatic tissue showed similar marked changes. Glycogen concentration increased rapidly to a maximum of 157 mg/g fresh liver at 24 hours post-refeeding, then declined to 48 mg/g at 72 hours post-refeeding. Lipid concentration which increased during starvation decreased rapidly during the first 12 hours of refeeding, then increased to 69 to 88 mg/g liver at 72 to 96 hours after refeeding. Assays for glucokinase, isocitrate dehydrogenase (NADP-linked) and glucose-6-phosphate dehydrogenase revealed differential responses in activity during realimentation. The response in G-6-P-DH activity, however, was markedly affected by the protein content of the refeeding diet.

1 This investigation was supported by the U. S. Air Force under Contract no. 41 (609)2185, monitored by the Arctic Aeromedical Space Laboratory, Fort Wain-wright, Alaska. This is not an official publication under the contract. Views or opinions expressed herein are not to be construed as necessarily reflecting the views or endorsement of the Department of the Air Force or of the Arctic Aeromedical Space Laboratory.

2 Present address: Department of Animal Science, Macdonald College, Province of Quebec, Canada.

Manuscript received 6 May 1965.




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