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Effects of Dietary Lipid and Diethylstilbestrol upon Liver Fatty Acids of Choline-deficient Rats¹

Division of Biochemistry, University of Wyoming, Laramie, Wyoming

The effects of various dietary lipids upon the composition of liver fatty acids in choline-supplemented and choline-deficient rats with and without diethylstilbestrol (DES) treatment, are presented and discussed. Changes in liver fatty acids of choline-deficient rats receiving different dietary lipids appear to be due to specific accumulation of triglycerides with their characteristic fatty acid compositions. In most cases DES treatment resulted in increases in liver monoenoic acids and decreases in stearic and arachidonic acids, particularly in the cholesterol ester fraction. However, these fatty acid effects appeared to be unrelated to the lipotropic action of DES.

Manuscript received 1 March 1965.