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Cardiovascular Lesions, Blood Lipids, Coagulation and Fibrinolysis in Butter-induced Obesity in the Rat¹

Pratt Clinic-New England Center Hospital and the Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts

A study was made of obesity in the rat, induced by feeding a high butter fat diet over a long period and possible effects of obesity on the development of cardiovascular lesions. A group of 17 male Wistar albino rats was fed a diet that contained 40% butter by weight (providing about 65% of the calories). To evaluate the independent contribution of obesity to the development of cardiovascular disease, repeated measurements were made of other parameters that might be affected by fats, namely, blood lipids, coagulation and fibrinolysis. The animals became grossly obese but did not develop any significant changes in blood lipids, coagulation and fibrinolysis throughout the period of the experiment (average of 428 days). Nor were there any significant cardiovascular lesions at the end of this period, beyond those normally observed in the aging rat. It was concluded that under the conditions of this experiment where no significant changes occurred in blood lipids, coagulation and fibrinolysis, butter-induced obesity in the rat does not materially predispose to the development of cardiovascular lesions.

Manuscript received 8 March 1965.