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Effects of Copper, Molybdenum, and Zinc on Zinc-65 Tissue Distribution and Excretion in the Rat

U. S. Army Medical Research and Nutrition Laboratory, Fitzsimons General Hospital, Denver, Colorado

Tissue distribution and excretion of injected Zn⁶⁵ have been studied in both male and female rats maintained with increased dietary levels of different combinations of 3 mineral nutrients: copper (100 mg/kg), molybdenum (800 mg/kg), and zinc (5000 mg/kg). Results obtained indicate that diets high in zinc caused a significant increase in bone retention and urinary excretion and a significant decrease in soft tissue retention of intraperitoneally injected Zn⁶⁵. Increased dietary levels of copper or molybdenum or both, did not elicit a similar effect. Significant growth retardation was observed only in animals maintained with a ration high in both molybdenum and zinc.

Manuscript received 20 January 1965.