QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Sidransky, H. Articles by Verney, E. Search for Related Content PubMed PubMed Citation Articles by Sidransky, H. Articles by Verney, E.

Chemical Pathology of Acute Amino Acid Deficiencies

VIII. Influence of Amino Acid Intake on the Morphologic and Biochemical Changes in Young Rats Force-Fed a Threonine-Devoid Diet¹

Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania

Young rats of the Sprague-Dawley strain were force-fed for 3 days purified diets devoid of threonine and containing low (9%), normal (16%) or high (28%) levels of amino acids. With feeding the experimental diets, the ratio of carbohydrate (dextrin) to amino acids became 8:1 in the low, 4:1 in the normal, and 2:1 in the high amino acid diets. All animals developed fatty liver with a periportal distribution, increased hepatic glycogen, and atrophy of the pancreas, submaxillary gland, stomach, spleen, and thymus. The results indicate that the level of amino acid intake did not alter appreciably the pathologic changes caused by the threonine deficiency.

Manuscript received 2 November 1964.

This article has been cited by other articles:

				A. R. Tovar, C. Ascencio, and N. Torres Soy protein, casein, and zein regulate histidase gene expression by modulating serum glucagon Am J Physiol Endocrinol Metab, November 1, 2002; 283(5): E1016 - E1022. [Abstract] [Full Text] [PDF]